Rather, it is produced from a side reaction of the glycolytic intermediate fructose-6-phosphate. This allows red blood cells to have an easier time releasing O 2 to tissues that are in need of it.įructose-2,6-bisphosphate is not a product of the PPP. One major function of 2,3-BPG is to bind hemoglobin and reduce its affinity for O 2. Glutathione, as mentioned previously, is not produced by the PPP however, it does use the NADPH produced by the PPP to maintain its reduced form within the cell, which, in turn, maintains a predominately reducing environment within the cell. 2,3-bisphosphoglycerate is an intermediate of glycolysis, not the PPP. These two molecules are carriers of high-energy electrons, which are used to generate ATP via the electron transport chain. NADH and FADH 2 are not produced by the PPP, but rather are produced by the oxidation of glucose via the aerobic respiration pathway. Furthermore, ribose-5-phosphate is used as a major precursor for the synthesis of nucleotides. This, in turn, helps maintain a reducing environment within cells.
The pentose phosphate pathway (PPP) is a metabolic pathway in cells that is used to generate NADPH and/or ribose-5-phosphate for use in the cell, depending on the cell's needs. NADPH is used primarily to provide reducing power for several biosynthetic reactions, but it also serves as a means to keep glutathione predominately in its reduced form in the cell.
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